Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death.

ABSTRACT: In the past few years, overwhelming evidence has accrued that a high level of expression of the protein neuroglobin protects neurons in vitro, in animal models, and in humans, against cell death associated with hypoxic and amyloid insult. However, until now, the exact mechanism of neuroglobin's protective action has not been determined. Using cell biology and biochemical approaches we demonstrate that neuroglobin inhibits the intrinsic pathway of apoptosis in vitro and intervenes in activation of pro-caspase 9 by interaction with cytochrome c. Using systems level information of the apoptotic signalling reactions we have developed a quantitative model of neuroglobin inhibition of apoptosis, which simulates neuroglobin blocking of apoptosome formation at a single cell level. Furthermore, thi

SUBMITTER: Raychaudhuri S 

PROVIDER: S-EPMC2845893 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature