Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer.

ABSTRACT:

Background

Genetic factors play important roles in lung cancer susceptibility. In this study, we replicated the association of 5p15.33 and 6p21.33 with familial lung cancer. Taking into account the previously identified genetic susceptibility variants on 6q23-25/RGS17 and 15q24-25.1, we further determined the cumulative association of these four genetic regions and the population attributable risk percent of familial lung cancer they account for.

Methods

One hundred ninety-four case patients and 219 cancer-free control subjects from the Genetic Epidemiology of Lung Cancer Consortium were used for the association analysis. Each familial case was chosen from one high-risk lung cancer family that has three or more affected members. Single nucleotide polymorphisms (SNP) on chrom

SUBMITTER: Liu P 

PROVIDER: S-EPMC2846747 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature