Publication bias in reports of animal stroke studies leads to major overstatement of efficacy.

ABSTRACT: The consolidation of scientific knowledge proceeds through the interpretation and then distillation of data presented in research reports, first in review articles and then in textbooks and undergraduate courses, until truths become accepted as such both amongst "experts" and in the public understanding. Where data are collected but remain unpublished, they cannot contribute to this distillation of knowledge. If these unpublished data differ substantially from published work, conclusions may not reflect adequately the underlying biological effects being described. The existence and any impact of such "publication bias" in the laboratory sciences have not been described. Using the CAMARADES (Collaborative Approach to Meta-analysis and Review of Animal Data in Experimental Studies) database

SUBMITTER: Sena ES 

PROVIDER: S-EPMC2846857 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature