MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment.

ABSTRACT:

Background

MFSD2A (major facilitator superfamily domain containing 2) gene maps on chromosome 1p34 within a linkage disequilibrium block containing genetic elements associated with progression of lung cancer.

Results

Here we show that MFSD2A expression is strongly downregulated in non-small cell lung cancer cell lines of different histotypes and in primary lung adenocarcinomas. Experimental modulation of MFSD2A in lung cancer cells is associated with alteration of mRNA levels of genes involved in cell cycle control and interaction with the extracellular matrix. Exogenous expression of MFSD2A in lung cancer cells induced a G1 block, impaired adhesion and migration in vitro, and significantly reduced tumor colony number in vitro (4- to 27-fold, P < 0.0001) and tumor volume in

SUBMITTER: Spinola M 

PROVIDER: S-EPMC2846890 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature