Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland.

ABSTRACT:

Background

Coliform bacteria are the most common etiologic agents in severe mastitis of cows. Escherichia coli infections are mostly restricted to a single udder quarter whereas neighboring quarters stay clinically inapparent, implicating the presence of a systemic defense reaction. To address its underlying mechanism, we performed a transcriptome study of mammary tissue from udder quarters inoculated with E. coli (6 h and 24 h post infection), from neighboring quarters of the same animals, and from untreated control animals.

Results

After 6 h 13 probe sets of differentially expressed genes (DEG) were detected in infected quarters versus control animals. Eighteen hours later 2154 and 476 DEG were found in infected and in neighboring quarters vs. control animals. Cluster anal

SUBMITTER: Mitterhuemer S 

PROVIDER: S-EPMC2846913 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature