Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes.

ABSTRACT:

Background

Chaperonin proteins are well known for the critical role they play in protein folding and in disease. However, the recent identification of three diverged chaperonin paralogs associated with the human Bardet-Biedl and McKusick-Kaufman Syndromes (BBS and MKKS, respectively) indicates that the eukaryotic chaperonin-gene family is larger and more differentiated than previously thought. The availability of complete genome sequences makes possible a definitive characterization of the complete set of chaperonin sequences in human and other species.

Results

We identified fifty-four chaperonin-like sequences in the human genome and similar numbers in the genomes of the model organisms mouse and rat. In mammal genomes we identified, besides the well-known CCT chaperonin ge

SUBMITTER: Mukherjee K 

PROVIDER: S-EPMC2846930 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature