RBC and WBC fatty acid composition following consumption of an omega 3 supplement: lessons for future clinical trials.

ABSTRACT:

Background

Results from increasing numbers of in vitro and in vivo studies have demonstrated that omega 3 fatty acids incorporated in cell culture media or in the diet of the animals can suppress the growth of cancers. When human clinical trials are initiated to determine the ability of omega 3 fatty acids to alter growth or response to chemotherapeutic interventions of cancers, it will be essential to determine the omega 3 intake of individuals in the trial to determine compliance with consumption of the supplement and to correlate with endpoints of efficacy. We wondered if the fatty acid composition of RBCs might accurately indicate incorporation of omega 3 fatty acids in the WBCs. In this report we determine and compare the changes in fatty acid compositions of red blood cells a

SUBMITTER: Witte TR 

PROVIDER: S-EPMC2846941 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature