FlexSnap: flexible non-sequential protein structure alignment.

ABSTRACT:

Background

Proteins have evolved subject to energetic selection pressure for stability and flexibility. Structural similarity between proteins that have gone through conformational changes can be captured effectively if flexibility is considered. Topologically unrelated proteins that preserve secondary structure packing interactions can be detected if both flexibility and Sequential permutations are considered. We propose the FlexSnap algorithm for flexible non-topological protein structural alignment.

Results

The effectiveness of FlexSnap is demonstrated by measuring the agreement of its alignments with manually curated non-sequential structural alignments. FlexSnap showed competitive results against state-of-the-art algorithms, like DALI, SARF2, MultiProt, FlexProt, and FA

SUBMITTER: Salem S 

PROVIDER: S-EPMC2846951 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature