International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.

ABSTRACT:

Background

Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected because of their prior evidence of an association with lung cancer. These variants belonged to candidate genes from different cancer-related pathways including inflammation (IL1B), folate metabolism (MTHFR), regulatory function (AKAP9 and CAMKK1), cell adhesion (SEZL6) and apoptosis (FAS, FASL, TP53, TP53BP1 and BAT3).

Methods

Genotype data from 15 ILCCO case-control studies were available for a total of 8431 lung cancer cases and 11 072 controls of European descent

SUBMITTER: Truong T 

PROVIDER: S-EPMC2847090 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature