The differential diagnosis and surveillance of hereditary gastrointestinal polyposis syndromes.

ABSTRACT:

Background

Hereditary gastrointestinal polyposis syndromes account for about 1% of all cases of colorectal cancer and are associated with a broad spectrum of extracolonic tumors. The early detection and accurate classification of these syndromes are essential, since effective methods for surveillance and treatment are available.

Methods

This review article is based on a selective literature search, the author's own work, and evidence-based guidelines and recommendations.

Results and conclusions

The diagnosis is initially suspected on the basis of the endoscopic findings and polyp histology. Because different syndromes can resemble each other phenotypically, e.g., autosomal dominant familial adenomatous polyposis and autosomal recessive MUTYH-associated polyposis, mole

SUBMITTER: Aretz S 

PROVIDER: S-EPMC2847323 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature