Noninvasive characterization of in situ forming implants using diagnostic ultrasound.

ABSTRACT: In situ forming drug delivery systems provide a means by which a controlled release depot can be physically inserted into a target site without the use of surgery. The release rate of drugs from these systems is often related to the rate of implant formation. Currently, only a limited number of techniques are available to monitor phase inversion, and none of these methods can be used to visualize the process directly and noninvasively. In this study, diagnostic ultrasound was used to visualize and quantify the process of implant formation in a phase inversion based system both in vitro and in vivo. Concurrently, sodium fluorescein was used as a mock drug to evaluate the drug release profiles and correlate drug release and implant formation processes. Implants comprised of three different m

SUBMITTER: Solorio L 

PROVIDER: S-EPMC2847659 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature