Ontology highlight
ABSTRACT:
SUBMITTER: Rakyan VK
PROVIDER: S-EPMC2847746 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Genome research 20100310 4
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery cohort, and then replicate these aDMRs in sorted CD4(+) T-cells and CD14(+) monocytes in an independent cohort, suggesting that aDMRs occur in precursor haematopoietic cells. Further replication of th ...[more]