Dispersion as an important step in the Candida albicans biofilm developmental cycle.

ABSTRACT: Biofilms are dynamic microbial communities in which transitions between planktonic and sessile modes of growth occur interchangeably in response to different environmental cues. In the last decade, early events associated with C. albicans biofilm formation have received considerable attention. However, very little is known about C. albicans biofilm dispersion or the mechanisms and signals that trigger it. This is important because it is precisely C. albicans cells dispersed from biofilms that are the main culprits associated with candidemia and establishment of disseminated invasive disease, two of the gravest forms of candidiasis. Using a simple flow biofilm model recently developed by our group, we have performed initial investigations into the phenomenon of C. albicans biofilm dispersio

SUBMITTER: Uppuluri P 

PROVIDER: S-EPMC2847914 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature