Biosynthesis of 2-hydroxyisobutyric acid (2-HIBA) from renewable carbon.

ABSTRACT: Nowadays a growing demand for green chemicals and cleantech solutions is motivating the industry to strive for biobased building blocks. We have identified the tertiary carbon atom-containing 2-hydroxyisobutyric acid (2-HIBA) as an interesting building block for polymer synthesis. Starting from this carboxylic acid, practically all compounds possessing the isobutane structure are accessible by simple chemical conversions, e. g. the commodity methacrylic acid as well as isobutylene glycol and oxide. During recent years, biotechnological routes to 2-HIBA acid have been proposed and significant progress in elucidating the underlying biochemistry has been made. Besides biohydrolysis and biooxidation, now a bioisomerization reaction can be employed, converting the common metabolite 3-hydroxybut

SUBMITTER: Rohwerder T 

PROVIDER: S-EPMC2847961 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature