Promiscuity of enhancer, coding and non-coding transcription functions in ultraconserved elements.

ABSTRACT:

Background

Ultraconserved elements (UCEs) are highly constrained elements of mammalian genomes, whose functional role has not been completely elucidated yet. Previous studies have shown that some of them act as enhancers in mouse, while some others are expressed in both normal and cancer-derived human tissues. Only one UCE element so far was shown to present these two functions concomitantly, as had been observed in other isolated instances of single, non ultraconserved enhancer elements.

Results

We used a custom microarray to assess the levels of UCE transcription during mouse development and integrated these data with published microarray and next-generation sequencing datasets as well as with newly produced PCR validation experiments. We show that a large fraction of non-

SUBMITTER: Licastro D 

PROVIDER: S-EPMC2847969 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature