Genome dynamics of Bartonella grahamii in micro-populations of woodland rodents.

ABSTRACT:

Background

Rodents represent a high-risk reservoir for the emergence of new human pathogens. The recent completion of the 2.3 Mb genome of Bartonella grahamii, one of the most prevalent blood-borne bacteria in wild rodents, revealed a higher abundance of genes for host-cell interaction systems than in the genomes of closely related human pathogens. The sequence variability within the global B. grahamii population was recently investigated by multi locus sequence typing, but no study on the variability of putative host-cell interaction systems has been performed.

Results

To study the population dynamics of B. grahamii, we analyzed the genomic diversity on a whole-genome scale of 27 B. grahamii strains isolated from four different species of wild rodents in three geographic lo

SUBMITTER: Berglund EC 

PROVIDER: S-EPMC2847970 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature