Evaluation of DOK5 as a susceptibility gene for type 2 diabetes and obesity in North Indian population.

ABSTRACT:

Background

Type 2 diabetes is a complex metabolic disorder with obesity being a major contributing factor in its development. Susceptibility loci for type 2 diabetes and obesity have been localized on different chromosomal regions by various genome-wide linkage scans. Of these chromosomal regions, 20q13 is one of the strongest linked regions for type 2 diabetes as well as obesity. On 20q13 lies DOK5 that seems to be a strong functional and positional candidate for type 2 diabetes and obesity because of its involvement in insulin signaling and immune responses. Hence, for the first time, we explored DOK5 as a potential type 2 diabetes and obesity susceptibility gene.

Methods

We sequenced 43 subjects for polymorphisms in functionally relevant regions of DOK5. A total of 10 SNP

SUBMITTER: Tabassum R 

PROVIDER: S-EPMC2848002 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature