Choline PET based dose-painting in prostate cancer--modelling of dose effects.

ABSTRACT:

Background

Several randomized trials have documented the value of radiation dose escalation in patients with prostate cancer, especially in patients with intermediate risk profile. Up to now dose escalation is usually applied to the whole prostate. IMRT and related techniques currently allow for dose escalation in sub-volumes of the organ. However, the sensitivity of the imaging modality and the fact that small islands of cancer are often dispersed within the whole organ may limit these approaches with regard to a clear clinical benefit. In order to assess potential effects of a dose escalation in certain sub-volumes based on choline PET imaging a mathematical dose-response model was developed.

Methods

Based on different assumptions for alpha/beta, gamma 50, sensitivity and

SUBMITTER: Niyazi M 

PROVIDER: S-EPMC2848061 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature