Cognitive decline in incident Alzheimer disease in a community population.

ABSTRACT:

Objective

To measure the cognitive consequences of incident Alzheimer disease (AD) in older African American and white subjects.

Methods

Data are from the Chicago Health and Aging Project, a longitudinal cohort study of older white and black persons residing in a geographically defined community. At 3-year intervals, the entire study population completed 4 brief cognitive tests, from which a previously established composite measure of global cognition was derived, and a subset underwent detailed clinical evaluation that supported clinical classification of mild cognitive impairment, dementia, and AD. We used mixed-effects models to examine change in cognitive function following the diagnostic evaluation.

Results

On clinical evaluation, 614 persons were found to have n

SUBMITTER: Wilson RS 

PROVIDER: S-EPMC2848102 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature