Anti-inflammatory drugs and risk of Parkinson disease: a meta-analysis.

ABSTRACT:

Background/objective

Anti-inflammatory drugs may prevent Parkinson disease (PD) by inhibiting a putative underlying neuroinflammatory process. We tested the hypothesis that anti-inflammatory drugs reduce PD incidence and that there are differential effects by type of anti-inflammatory, duration of use, or intensity of use.

Methods

MEDLINE and EMBASE were searched for studies that reported risk of PD associated with anti-inflammatory medications. Random-effects meta-analyses were used to pool results across studies for each type of anti-inflammatory drug. Stratified meta-analyses were used to assess duration- and intensity-response.

Results

Seven studies were identified that met the inclusion criteria, all of which reported associations between nonaspirin nonsteroidal

SUBMITTER: Gagne JJ 

PROVIDER: S-EPMC2848103 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature