Persistent organochlorine pesticides in serum and risk of Parkinson disease.

ABSTRACT:

Background

Pesticides have been implicated as likely environmental risk factors for Parkinson disease (PD), but assessment of past exposure to pesticides can be difficult. No prior studies of pesticide exposure and PD used biomarkers of exposure collected before the onset of PD. Our investigation examined the association between prospective serum biomarkers of organochlorine pesticides and PD.

Methods

We conducted a nested case-control study within the Finnish Mobile Clinic Health Examination Survey, with serum samples collected during 1968-1972, and analyzed in 2005-2007 for organochlorine pesticides. Incident PD cases were identified through the Social Insurance Institution's nationwide registry and were confirmed by review of medical records (n = 101). Controls (n = 349)

SUBMITTER: Weisskopf MG 

PROVIDER: S-EPMC2848105 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature