SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells.

ABSTRACT:

Background

The vertebrate pancreas contains islet, acinar and ductal cells. These cells derive from a transient pool of multipotent pancreatic progenitors during embryonic development. Insight into the genetic determinants regulating pancreatic organogenesis will help the development of cell-based therapies for the treatment of diabetes mellitus. Suppressor enhancer lin12/Notch 1 like (Sel1l) encodes a cytoplasmic protein that is highly expressed in the developing mouse pancreas. However, the morphological and molecular events regulated by Sel1l remain elusive.

Results

We have characterized the pancreatic phenotype of mice carrying a gene trap mutation in Sel1l. We show that Sel1l expression in the developing pancreas coincides with differentiation of the endocrine and exocr

SUBMITTER: Li S 

PROVIDER: S-EPMC2848149 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature