Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblastogenesis.

ABSTRACT:

Background

The mineralized skeleton is a major evolutionary novelty that has contributed to the impressive morphological diversifications of the vertebrates. Essential to bone biology is the solidified extracellular matrix secreted by highly specialized cells, the osteoblasts. We now have a rather complete view of the events underlying osteogenesis, from a cellular, molecular, genetic, and epigenetic perspective. Because this knowledge is still largely restricted to mammals, it is difficult, if not impossible, to deduce the evolutionary history of the regulatory network involved in osteoblasts specification and differentiation. In this study, we focused on the transcriptional regulators Runx2 and VDR (the Vitamin D Receptor) that, in mammals, directly interact together and stabiliz

SUBMITTER: Marcellini S 

PROVIDER: S-EPMC2848158 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature