A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.

ABSTRACT:

Background

Serum creatinine (S CR) is the most important biomarker for a quick and non-invasive assessment of kidney function in population-based surveys. A substantial proportion of the inter-individual variability in S CR level is explicable by genetic factors.

Methods

We performed a meta-analysis of genome-wide association studies of S CR undertaken in five population isolates ('discovery cohorts'), all of which are part of the European Special Population Network (EUROSPAN) project. Genes showing the strongest evidence for an association with SCR (candidate loci) were replicated in two additional population-based samples ('replication cohorts').

Results

After the discovery meta-analysis, 29 loci were selected for replication. Association between SCR level and polym

SUBMITTER: Pattaro C 

PROVIDER: S-EPMC2848223 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature