Functional annotation of novel lineage-specific genes using co-expression and promoter analysis.

ABSTRACT:

Background

The diversity of placental architectures within and among mammalian orders is believed to be the result of adaptive evolution. Although, the genetic basis for these differences is unknown, some may arise from rapidly diverging and lineage-specific genes. Previously, we identified 91 novel lineage-specific transcripts (LSTs) from a cow term-placenta cDNA library, which are excellent candidates for adaptive placental functions acquired by the ruminant lineage. The aim of the present study was to infer functions of previously uncharacterized lineage-specific genes (LSGs) using co-expression, promoter, pathway and network analysis.

Results

Clusters of co-expressed genes preferentially expressed in liver, placenta and thymus were found using 49 previously uncharacteriz

SUBMITTER: Kumar CG 

PROVIDER: S-EPMC2848242 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature