Whole genome evaluation of horizontal transfers in the pathogenic fungus Aspergillus fumigatus.

ABSTRACT:

Background

Numerous cases of horizontal transfers (HTs) have been described for eukaryote genomes, but in contrast to prokaryote genomes, no whole genome evaluation of HTs has been carried out. This is mainly due to a lack of parametric methods specially designed to take the intrinsic heterogeneity of eukaryote genomes into account. We applied a simple and tested method based on local variations of genomic signatures to analyze the genome of the pathogenic fungus Aspergillus fumigatus.

Results

We detected 189 atypical regions containing 214 genes, accounting for about 1 Mb of DNA sequences. However, the fraction of atypical DNA detected was smaller than the average amount detected in the same conditions in prokaryote genomes (3.1% vs 5.6%). It appeared that about one third o

SUBMITTER: Mallet LV 

PROVIDER: S-EPMC2848249 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature