Identification of key genes for carcinogenic pathways associated with colorectal adenoma-to-carcinoma progression.

ABSTRACT: Colorectal adenomas form a biologically and clinically distinct intermediate stage in development of colorectal cancer (CRC) from normal colon epithelium. Only 5% of adenomas progress into adenocarcinomas, indicating that malignant transformation requires other biological alterations than those involved in adenoma formation. The present study aimed to explore which cancer-related biological processes are affected during colorectal adenoma-to-carcinoma progression and to identify key genes within these pathways that can serve as tumor markers for malignant transformation. The activity of 12 cancer-related biological processes was compared between 37 colorectal adenomas and 31 adenocarcinomas, using the pathway analysis tool Gene Set Enrichment Analysis. Expression of six gene sets was signi

SUBMITTER: Sillars-Hardebol AH 

PROVIDER: S-EPMC2848338 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature