Organism-scale modeling of early Drosophila patterning via bone morphogenetic proteins.

ABSTRACT: Advances in image acquisition and informatics technology have led to organism-scale spatiotemporal atlases of gene expression and protein distributions. To maximize the utility of this information for the study of developmental processes, a new generation of mathematical models is needed for discovery and hypothesis testing. Here, we develop a data-driven, geometrically accurate model of early Drosophila embryonic bone morphogenetic protein (BMP)-mediated patterning. We tested nine different mechanisms for signal transduction with feedback, eight combinations of geometry and gene expression prepatterns, and two scale-invariance mechanisms for their ability to reproduce proper BMP signaling output in wild-type and mutant embryos. We found that a model based on positive feedback of a secrete

SUBMITTER: Umulis DM 

PROVIDER: S-EPMC2848394 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature