The origins of time-delay in template biopolymerization processes.

ABSTRACT: Time-delays are common in many physical and biological systems and they give rise to complex dynamic phenomena. The elementary processes involved in template biopolymerization, such as mRNA and protein synthesis, introduce significant time delays. However, there is not currently a systematic mapping between the individual mechanistic parameters and the time delays in these networks. We present here the development of mathematical, time-delay models for protein translation, based on PDE models, which in turn are derived through systematic approximations of first-principles mechanistic models. Theoretical analysis suggests that the key features that determine the time-delays and the agreement between the time-delay and the mechanistic models are ribosome density and distribution, i.e., the n

SUBMITTER: Mier-y-Teran-Romero L 

PROVIDER: S-EPMC2848540 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature