Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs.

ABSTRACT:

Background

Alveolar echinococcosis (AE) is a severe chronic hepatic parasitic disease currently emerging in central and eastern Europe. Untreated AE presents a high mortality (>90%) due to a severe hepatic destruction as a result of parasitic metacestode proliferation which behaves like a malignant tumor. Despite this severe course and outcome of disease, the genetic program that regulates the host response leading to organ damage as a consequence of hepatic alveolar echinococcosis is largely unknown.

Methodology/principal findings

We used a mouse model of AE to assess gene expression profiles in the liver after establishment of a chronic disease status as a result of a primary peroral infection with eggs of the fox tapeworm Echinococcus multilocularis. Among 38 genes differ

SUBMITTER: Gottstein B 

PROVIDER: S-EPMC2848562 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature