Ontology highlight
ABSTRACT:
SUBMITTER: Li CH
PROVIDER: S-EPMC2848580 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
PloS one 20100401 4
Stress granules (SGs) are cytoplasmic foci at which untranslated mRNAs accumulate in cells exposed to environmental stress. We have identified ornithine decarboxylase (ODC), an enzyme required for polyamine synthesis, and eIF5A, a polyamine (hypusine)-modified translation factor, as proteins required for arsenite-induced SG assembly. Knockdown of deoxyhypusine synthase (DHS) or treatment with a deoxyhypusine synthase inhibitor (GC7) prevents hypusine modification of eIF5A as well as arsenite-ind ...[more]