The Puf family of RNA-binding proteins in plants: phylogeny, structural modeling, activity and subcellular localization.

ABSTRACT:

Background

Puf proteins have important roles in controlling gene expression at the post-transcriptional level by promoting RNA decay and repressing translation. The Pumilio homology domain (PUM-HD) is a conserved region within Puf proteins that binds to RNA with sequence specificity. Although Puf proteins have been well characterized in animal and fungal systems, little is known about the structural and functional characteristics of Puf-like proteins in plants.

Results

The Arabidopsis and rice genomes code for 26 and 19 Puf-like proteins, respectively, each possessing eight or fewer Puf repeats in their PUM-HD. Key amino acids in the PUM-HD of several of these proteins are conserved with those of animal and fungal homologs, whereas other plant Puf proteins demonstrate extens

SUBMITTER: Tam PP 

PROVIDER: S-EPMC2848763 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature