Lynch syndrome-associated breast cancers: clinicopathologic characteristics of a case series from the colon cancer family registry.

ABSTRACT:

Purpose

The recognition of breast cancer as a spectrum tumor in Lynch syndrome remains controversial. The aim of this study was to explore features of breast cancers arising in Lynch syndrome families.

Experimental design

This observational study involved 107 cases of breast cancer identified from the Colorectal Cancer Family Registry (Colon CFR) from 90 families in which (a) both breast and colon cancer co-occurred, (b) families met either modified Amsterdam criteria, or had at least one early-onset (<50 years) colorectal cancer, and (c) breast tissue was available within the biospecimen repository for mismatch repair (MMR) testing. Eligibility criteria for enrollment in the Colon CFR are available online. Breast cancers were reviewed by one pathologist. Tumor sections were

SUBMITTER: Walsh MD 

PROVIDER: S-EPMC2848890 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature