MiR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging.

ABSTRACT: Aging is a multifactorial process where deterioration of body functions is driven by stochastic damage while counteracted by distinct genetically encoded repair systems. To better understand the genetic component of aging, many studies have addressed the gene and protein expression profiles of various aging model systems engaging different organisms from yeast to human. The recently identified small non-coding miRNAs are potent post-transcriptional regulators that can modify the expression of up to several hundred target genes per single miRNA, similar to transcription factors. Increasing evidence shows that miRNAs contribute to the regulation of most if not all important physiological processes, including aging. However, so far the contribution of miRNAs to age-related and senescence-rela

SUBMITTER: Hackl M 

PROVIDER: S-EPMC2848978 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature