Meiotic behavior of aneuploid chromatin in mouse models of Down syndrome.

ABSTRACT: Aneuploidy, which leads to unpaired chromosomal axes during meiosis, is frequently accompanied by infertility. We previously showed, using three mouse models of Down syndrome, that it is an extra chromosome, but not extra gene dose, that is associated with male infertility and virtual absence of post-meiotic gem cells. Here, we test the hypothesis that aneuploid segments are differentially modified and expressed during meiosis, depending on whether they are present as an extra chromosome or not. In all three models examined, the trisomic region lacks a pairing partner, but in one case, spermatocytes have an extra (and unpaired) chromosome, while the two other models involve translocation of the trisomic region rather than an extra chromosome. An extra unpaired chromosome was always modifie

SUBMITTER: Reinholdt LG 

PROVIDER: S-EPMC2848991 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature