Comparative genomic analyses of attenuated strains of Mycoplasma gallisepticum.

ABSTRACT: Mycoplasma gallisepticum is a significant respiratory and reproductive pathogen of domestic poultry. While the complete genomic sequence of the virulent, low-passage M. gallisepticum strain R (R(low)) has been reported, genomic determinants responsible for differences in virulence and host range remain to be completely identified. Here, we utilize genome sequencing and microarray-based comparative genomic data to identify these genomic determinants of virulence and to elucidate genomic variability among strains of M. gallisepticum. Analysis of the high-passage, attenuated derivative of R(low), R(high), indicated that relatively few total genomic changes (64 loci) occurred, yet they are potentially responsible for the observed attenuation of this strain. In addition to previously characteri

SUBMITTER: Szczepanek SM 

PROVIDER: S-EPMC2849401 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature