Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy.

ABSTRACT: The search for the genomic sequences involved in human cancers can be greatly facilitated by maps of genomic imbalances identifying the involved chromosomal regions, particularly those that participate in the development of occult preneoplastic conditions that progress to clinically aggressive invasive cancer. The integration of such regions with human genome sequence variation may provide valuable clues about their overall structure and gene content. By extension, such knowledge may help us understand the underlying genetic components involved in the initiation and progression of these cancers. We describe the development of a genome-wide map of human bladder cancer that tracks its progression from in situ precursor conditions to invasive disease. Testing for allelic losses using a genome

SUBMITTER: Majewski T 

PROVIDER: S-EPMC2849658 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature