Cortical-striatal integration of cocaine history and prefrontal dysfunction in animal modeling of dual diagnosis.

ABSTRACT:

Background

High rates of substance disorders in schizophrenia and other mental illnesses may reflect biological vulnerabilities to the addiction process. Interactions between addictive drug effects and mental illness involving circuits that generate motivated behavior may underpin this vulnerability.

Methods

We examined separate and combined effects of neonatal ventral hippocampal lesions (NVHLs)-a neurodevelopmental model of schizophrenia (vs. SHAM-operated control animals)--and a behaviorally sensitizing cocaine history (15 mg/kg/day x 5 days vs. saline injections) on acute cocaine-induced neural activation signaled by c-Fos expression. Stereological assessment of activation densities spanned six ventral to dorsal cortical-striatal compartments.

Results

Cortically,

SUBMITTER: Chambers RA 

PROVIDER: S-EPMC2849854 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature