Ontology highlight
ABSTRACT:
SUBMITTER: Garbati MR
PROVIDER: S-EPMC2849871 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Cancer letters 20091130 2
Human c-Rel (REL) is a member of the NF-kappaB family of transcription factors. REL's normal physiological role is in the regulation of B-cell proliferation and survival. The REL gene is amplified in many human B-cell lymphomas and overexpression of REL can transform chicken lymphoid cells. In this report, histone acetyltransferase p300 enhanced REL-induced transactivation and interacted with REL both in vitro and in REL-transformed chicken spleen cells and the B-lymphoma cell line RC-K8, in whi ...[more]