Action of modafinil--increased motivation via the dopamine transporter inhibition and D1 receptors?

ABSTRACT:

Background

Modafinil is prescribed for the treatment of narcolepsy. It has been postulated that modafinil might treat cognitive disruption in neuropsychiatric disorders. The mechanisms underlying such modafinil-induced improvements in performance have yet to be delineated however. Recent evidence suggests that modafinil might block the dopamine transporter (DAT) and that the dopamine D1 receptor (D1R) might contribute to modafinil effects.

Methods

Dopamine D1R wildtype (WT), heterozygous (HT), and knockout (KO) mice received vehicle, modafinil, or the selective DAT blocker GBR12909 in a progressive ratio breakpoint study.

Results

Both modafinil and GBR12909 increased motivation in the task as measured by an increase in breakpoint in WT and HT mice. These drug-induced

SUBMITTER: Young JW 

PROVIDER: S-EPMC2849918 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature