Detection of hepatocellular carcinoma using glycomic analysis.

ABSTRACT:

Purpose

Hepatocellular carcinoma (HCC) represents an increasing health problem in the United States. Serum alpha-fetoprotein, the currently used clinical marker, is elevated in only approximately 60% of HCC patients; therefore, the identification of additional markers is expected to have significant public health impact. The objective of our study was to quantitatively assess N-glycans originating from serum glycoproteins as alternative markers for the detection of HCC.

Experimental design

We used matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for quantitative comparison of 83 N-glycans in serum samples of 202 participants (73 HCC cases, 77 age- and gender-matched cancer-free controls, and 52 patients with chronic liver disease). N-glycans were

SUBMITTER: Goldman R 

PROVIDER: S-EPMC2850198 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature