Plasma superoxide dismutase-1 as a surrogate marker of vivax malaria severity.

ABSTRACT:

Background

Severe outcomes have been described for both Plasmodium falciparum and P. vivax infections. The identification of sensitive and reliable markers of disease severity is fundamental to improving patient care. An intense pro-inflammatory response with oxidative stress and production of reactive oxygen species is present in malaria. Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and antioxidant agents such as superoxide dismutase-1 (SOD-1) are likely candidate biomarkers for disease severity. Here we tested whether plasma levels of SOD-1 could serve as a biomarker of severe vivax malaria.

Methodology/principal findings

Plasma samples were obtained from residents of the Brazilian Amazon with a high risk for P. vivax transmission. Malaria diagnos

SUBMITTER: Andrade BB 

PROVIDER: S-EPMC2850307 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature