Characterization of the ovine ribosomal protein SA gene and its pseudogenes.

ABSTRACT:

Background

The ribosomal protein SA (RPSA), previously named 37-kDa laminin receptor precursor/67-kDa laminin receptor (LRP/LR) is a multifunctional protein that plays a role in a number of pathological processes, such as cancer and prion diseases. In all investigated species, RPSA is a member of a multicopy gene family consisting of one full length functional gene and several pseudogenes. Therefore, for studies on RPSA related pathways/pathologies, it is important to characterize the whole family and to address the possible function of the other RPSA family members. The present work aims at deciphering the RPSA family in sheep.

Results

In addition to the full length functional ovine RPSA gene, 11 other members of this multicopy gene family, all processed pseudogenes, were i

SUBMITTER: Van den Broeke A 

PROVIDER: S-EPMC2850357 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature