Vascular CXCR4 expression - a novel antiangiogenic target in gastric cancer?

ABSTRACT:

Background

G-protein-coupled receptors (GPCRs) are prime candidates for novel cancer prevention and treatment strategies. We searched for differentially expressed GPCRs in node positive gastric carcinomas.

Methodology/principal findings

Differential expression of GPCRs in three node positive vs. three node negative intestinal type gastric carcinomas was analyzed by gene array technology. The candidate genes CXCL12 and its receptor CXCR4 were validated by real-time reverse-transcription polymerase chain reaction in an independent set of 37 gastric carcinomas. Translation was studied by immunohistochemistry in 347 gastric carcinomas using tissue microarrays as well as in 61 matching lymph node metastases. Protein expression was correlated with clinicopathological patient chara

SUBMITTER: Ingold B 

PROVIDER: S-EPMC2851611 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature