Joint estimation of DNA copy number from multiple platforms.

ABSTRACT:

Motivation

DNA copy number variants (CNVs) are gains and losses of segments of chromosomes, and comprise an important class of genetic variation. Recently, various microarray hybridization-based techniques have been developed for high-throughput measurement of DNA copy number. In many studies, multiple technical platforms or different versions of the same platform were used to interrogate the same samples; and it became necessary to pool information across these multiple sources to derive a consensus molecular profile for each sample. An integrated analysis is expected to maximize resolution and accuracy, yet currently there is no well-formulated statistical method to address the between-platform differences in probe coverage, assay methods, sensitivity and analytical complexity.

SUBMITTER: Zhang NR 

PROVIDER: S-EPMC2852203 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature