The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance.

ABSTRACT: Multiple organs contribute to the development of peripheral insulin resistance, with the major contributors being skeletal muscle, liver, and adipose tissue. Because insulin resistance usually precedes the development of type 2 diabetes mellitus (T2DM) by many years, understanding the pathophysiology of insulin resistance should enable development of therapeutic strategies to prevent disease progression. Some subjects with mitochondrial genomic variants/defects and a subset of lean individuals with hereditary predisposition to T2DM exhibit skeletal muscle mitochondrial dysfunction early in the course of insulin resistance. In contrast, in the majority of subjects with T2DM the plurality of evidence implicates skeletal muscle mitochondrial dysfunction as a consequence of perturbations assoc

SUBMITTER: Pagel-Langenickel I 

PROVIDER: S-EPMC2852205 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature