Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes.

ABSTRACT: The negative impact of obesity on reproductive success is well documented but the stages at which development of the conceptus is compromised and the mechanisms responsible for the developmental failure still remain unclear. Recent findings suggest that mitochondria may be a contributing factor. However to date no studies have directly addressed the consequences of maternal obesity on mitochondria in early embryogenesis.Using an established murine model of maternal diet induced obesity and a live cell dynamic fluorescence imaging techniques coupled with molecular biology we have investigated the underlying mechanisms of obesity-induced reduced fertility. Our study is the first to show that maternal obesity prior to conception is associated with altered mitochondria in mouse oocytes and zyg

SUBMITTER: Igosheva N 

PROVIDER: S-EPMC2852405 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature