Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity.

ABSTRACT:

Background

The growth hormone secretagogue receptor (GHSR) is mediating hunger sensation when stimulated by its natural ligand ghrelin. In the present study, we tested the hypothesis that common and rare variation in the GHSR locus are related to increased prevalence of obesity and overweight among Whites.

Methodology/principal findings

In a population-based study sample of 15,854 unrelated, middle-aged Danes, seven variants were genotyped to capture common variation in an 11 kbp region including GHSR. These were investigated for their individual and haplotypic association with obesity. None of these analyses revealed consistent association with measures of obesity. A -151C/T promoter mutation in the GHSR was found in two unrelated obese patients. One family presented with c

SUBMITTER: Gjesing AP 

PROVIDER: S-EPMC2852411 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature