Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans.

ABSTRACT: Acute respiratory infections (ARIs) are a common reason for seeking medical attention, and the threat of pandemic influenza will likely add to these numbers. Using human viral challenge studies with live rhinovirus, respiratory syncytial virus, and influenza A, we developed peripheral blood gene expression signatures that distinguish individuals with symptomatic ARIs from uninfected individuals with >95% accuracy. We validated this "acute respiratory viral" signature-encompassing genes with a known role in host defense against viral infections-across each viral challenge. We also validated the signature in an independently acquired data set for influenza A and classified infected individuals from healthy controls with 100% accuracy. In the same data set, we could also distinguish viral fro

SUBMITTER: Zaas AK 

PROVIDER: S-EPMC2852511 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature