Ontology highlight
ABSTRACT:
SUBMITTER: Borikova AL
PROVIDER: S-EPMC2852911 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20100224 16
Cerebral cavernous malformations (CCM) are vascular lesions causing seizures and stroke. Mutations causing inactivation of one of three genes, ccm1, -2, or -3, are sufficient to induce vascular endothelial cell defects resulting in CCM. Herein, we show that loss of expression of the CCM1, -2, or -3 proteins causes a marked increase in expression of the GTPase RhoA. Live cell imaging with a RhoA-specific biosensor demonstrates increased RhoA activity with loss of CCM1, -2, or -3, with an especial ...[more]